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Patil, S. M.
- Nanocapsules as a Novel Drug Delivery System
Authors
1 C/o-D. K. Mane’s house, Near Mukteshwar-Ashram, Vasant Nagar, Nanded 431602(MS), IN
2 Department of Pharmaceutics, ASPM’s K.T. Patil College of Pharmacy, Osmanabad 413501, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 146-155Abstract
Nanocapsules have been proposed as drug carrier that may be used as to realize magic bullet in 20th century, which refers to capable of targating a perticular and releasing its content when desired at site of action Nanocapsules prepared from preformed polymers as active substances carriers is presented. This entails a general review of the different preparation methods nanoprecipitation, emulsion-diffusion, double emulsification, emulsion-coacervation, polymer-coating and layer-by-layer, from the point of view of the methodological and mechanistic aspects involved. Encapsulation of the active substance and the raw materials used. Similarly, a comparative analysis is given of the size, zeta-potential, encapsulation efficiency, active substance Release, stability and in vivo and in vitro pharmacological performances, using as basis the data reported in the different research works published.Keywords
Nanocapsules, Encapsulation Efficiency, Zeta-Potential, Encapsulation Method.- Characterization and Evaluation of Glibenclamide Transmucosal Drug Delivery System
Authors
1 K.L.E’s College of Pharmacy, Nipani –591237, Dist: Belgaum, Karnataka, IN
2 K.L.E’s College of Pharmacy, Nipani, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 44-46Abstract
In an attempt to develop mucoadhesive buccal drug delivery system, buccal tablets of Glibenclamide were prepared using polymers such as carbopol-934, Hydroxypropylmethyl cellulose HPMCK4M, and sodium carboxy methyl cellulose (Sod. CMC) in various proportions and combinations. The tablets were evaluated for different physicochemical parameters like weight variation, friability, hardness, drug content, water absorption studies, bioadhesive performance, release characteristics and surface pH. Tablets containing carbopol-934 and sodium CMC showed a maximum in vitro release of 82.27%. The formulations were subjected to graphical treatments according to Higuchi's equation and Peppa's equation. The best formulation F1 confirmed that the release mechanism is by diffusion, the rate of release following first order kinetic model.